CERELA   05438
CENTRO DE REFERENCIA PARA LACTOBACILOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Oral administration of kefiran improve resistance to respiratory infection and respiratory innate immune response against to Streptococcus pneumonie
Autor/es:
KOLLING, YANINA; SALVA, SUSANA; ZAVALA, LUCIA; VILLENA, JULIO; PEREZ, PABLO; ABRAHAM, ANALIA; ALVAREZ SUSANA
Lugar:
Ciudad Autonoma de Buenos Aires
Reunión:
Congreso; LXIII Reunión Anual de la Sociedad Argentina de Inmunologia; 2015
Institución organizadora:
SAI. Sociedad Argentina de Inmunologia
Resumen:
Background: Kefiran is the main exopolysaccharide isolated from kefir grains. Oral administration induces changes on the balance of immune cells at intestinal mucosa. The aim of this study was to evaluate the effect of the oral administration of kefiran on resistance to respiratory infection and respiratory innate immune response against to Streptococcus pneumoniae (Sp). Methods: Six week-old Swiss mice were administered with kefiran (300 mg/L) for 0 and 2 days ad libitum (Control and kefiran groups). On day 3, all mice were infected nasally with Sp (109 UFC/mL/mouse). On day 2 post-infection we evaluated resistance to respiratory infection and innate immune response.Results: We demonstrated that treatment with kefiran significantly reduce lung Sp counts and tissue injuries after the challenge with Sp when compared to control group (p