Neuroprotective effects associated to immune modulation by selected lactic acid bacteria in a Parkinson's disease model

DE GIORI, GRACIELA SAVOY; VISÑUK, DAIANA PEREZ; DELEBLANC, ALEJANDRA DE MORENO; LEBLANC, JEAN GUY

NUTRITION

ELSEVIER SCIENCE INC

Año: 2020

0899-9007

ObjectivesParkinson´s Disease (PD) is a neurodegenerative process affecting motor function that involves an inflammatory response and B vitamins deficiencies. The aim of this study was to evaluate the effect of B-group vitamin producing and immunomodulatory lactic acid bacteria (LAB) in a murine model of PD.MethodsThe effect of Lactobacillus plantarum CRL 2130 (a riboflavin producer), Streptococcus thermophilus CRL 807 (an immunomodulatory strain) and Streptococcus thermophilus CRL 808 (a folate producer) were evaluated individually and as a mixture in mice injected with 1-methyl-4-fenil-1,2,3,6-tetrahidropiridina (MPTP). Motor capacity, tyrosine hydrolase (TH) in brain and cytokine concentrations in serum and in brain tissues were evaluated in MPTP treated mice after bacterial supplementation. Results: Mice receiving the selected LAB showed significantly improved motor skills compared to those that did not receive bacterial supplementation. When given the mixture of all 3 strains together, animals had higher brain TH+ cell counts, decreased the inflammatory cytokines IL-6 and TNF-α in serum and increased the anti-inflammatory cytokine IL-10 in serum and brain tissues compared to animals that did not receive LAB supplementation.ConclusionsThe results showed the potential of a selected LAB mixture to improve motor behavior and neuroinflammation in PD. This probiotic mixture could be used as an adjunct treatment in the control of PD.