CENTRO DE REFERENCIA PARA LACTOBACILOS
Unidad Ejecutora - UE
Evaluation of the effect of soymilk fermented by a riboflavin-producing Lactobacillus plantarum strain in a murine model of colitis
R. LEVIT; J.G. LEBLANC; G. SAVOY DE GIORI; A. DE MORENO DE LEBLANC
Wageningen Academic Publishers
Lugar: Wageningen; Año: 2017 vol. 8 p. 65 - 65
Inflammatory bowel diseases (IBD) are idiopathic diseases of the gastrointestinal tract characterized by recurrent inflammation that require lifelong treatments. It has been shown that certain strains of acid lactic bacteria (LAB) can produce specific health-promoting compounds in foods or in the gastrointestinal tract that can in turn prevent and/or treat IBD. This study was designed to evaluate the possible therapeutic potential of soymilk fermented by the riboflavin- producing strain Lactobacillus (L.) plantarum CRL 2130 in a trinitrobenzene sulfonic induced colitis mouse model. Mice that received soymilk fermented by L. plantarum CRL 2130 showed a decrease in weight loss, lower damage scores in their large intestines, lower microbial translocation to liver and decreased cytokines levels in their intestinal fluids compared to animals that received unfermented soymilk or soymilk fermented by a non-riboflavin-producing L. plantarum strain. This is the first report that demonstrates that a riboflavin-producing LAB was able to prevent experimental colitis in a murine model.