CENTRO DE REFERENCIA PARA LACTOBACILOS
Unidad Ejecutora - UE
Lactobacillus reuteri CRL 1098 prevents side effects produced by a nutritional vitamin B12 deficiency
MOLINA, VERÓNICA; MEDICI, MARTA; TARANTO, MARIA PIA; FONT DE VALDEZ, GRACIELA
JOURNAL OF APPLIED MICROBIOLOGY
Año: 2008 p. 77 - 77
Aims: To evaluate the efficiency of the vitamin B12-producing Lactobacillus reuteri CRL1098 strain to prevent the symptoms caused by a nutritional cobalamin deficient diet in pregnant female mice and their weaned offspring. Methods and results: Pregnant female mice were divided into three groups: animals fed with a B12-deficient diet (DD), animals fed with DD plus Lact. reuteri CRL1098, and animals fed with a B12-sufficient diet. The animals received the different feedings from the end of gestation up to weaning. At the end of the trials, they and their corresponding offspring were bled to determine haematological, immunological and histological parameters. The administration of the pseudovitamin B12-producing strain prevented the symptoms observed in female and weaned young animals fed with a nutritional B12 deficient diet. Conclusions: Our data suggest that the pseudovitamin B12 produced by Lact. reuteri CRL1098 is biologically active and effective to prevent the pathologies caused by the nutritional deficiency of B12 both in pregnant mice and their offspring. Significance and impact of the study: The ability of Lact. reuteri CRL1098 to prevent a nutritional vitamin deficiency was demonstrated for the first time. The addition of a GRAS microorganism to complement the B12 content in deficient foods is an interesting biotechnological alternative.