CERELA   05438
CENTRO DE REFERENCIA PARA LACTOBACILOS
Unidad Ejecutora - UE
artículos
Título:
Stimulation of respiratory immunity by oral administration of Lactococcus lactis
Autor/es:
VILLENA JULIO; MEDINA MARCELA; VINTIÑI ELISA; ALVAREZ SUSANA
Revista:
CANADIAN JOURNAL OF MICROBIOLOGY
Editorial:
NRC Research Press
Referencias:
Lugar: Saskatoon; Año: 2008 vol. 54 p. 630 - 630
ISSN:
0008-4166
Resumen:
This work demostrates that non-recombinant Lactococcus lactis NZ, administered by the oral route at the proper dose, is able to improve resistance against pneumococcal infection. L. lactis NZ oral administration was able to improve pathogen lung clearance, increased survival of infected mice and reduced lung injuries. This effect was related to an up-regulation of the respiratory innate and specific immune responses.  Administration of L. lactis NZ improved production of bronchoalveolar lavage fluid  (BAL) TNF-á, enhanced recruitment of neutrophils into the alveolar spaces and  induced a higher activation of BAL phagocytes compared to the control group. L. lactis  NZ administered orally stimulated the IgA cycle, increased IgA+ cells in intestine and  bronchus and improved production of BAL IL-4 and IL-10 during infection. Moreover, mice treated with L. lactis NZ showed higher levels of BAL anti-pneumococcal IgA and IgG. Taking into consideration that orally administered L. lactis NZ stimulates both the innate and the specific immune responses in the respiratory tract and that bacterial and  viral antigens have been efficiently produced in this strain, L. lactis NZ is an excellent  candidate for the development of an effective pneumococcal oral vaccine.  Keywords: Lactococcus lactis; oral adjuvant; Streptococcus pneumoniae; respiratory immunity