Disruption of Lipid Rafts Enhances the Effect of Lactobacilli on the Production of Tumor Necrosis Factor - Alpha in Mononuclear Blood Cells

MARIO SORIA, MÓNICA MECHOUD, ANGELA MARTÍN DE QUEVEDO, GRACIELA FONT DE VALDEZ AND ANA V. RODRIGUEZ

BIOSCIENCE, BIOTECHNOLOGY AND BIOCHEMISTRY

Japan Society for Bioscience, Biotechnology, and Agrochemistry

Lugar: Tokio, Japón; Año: 2008 vol. 72 p. 3293 - 3296

0916-8451

Disruption of Lipid Rafts Enhances the Effect of Lactobacilli on the Production of Tumor Necrosis Factor-Alpha in Mononuclear Blood Cells                                                              Mario SORIA1), Mónica MECHOUD1), Angela MARTIN DE QUEVEDO2), Graciela FONT DE VALDEZ1) and Ana V. RODRIGUEZ1) 1) Center of Reference for Lactobacilos (CERELA-CONICET) 2) Laboratorio Quevedo    We investigated, to determine whether disruption of lipid rafts would influence the effect of three selected strains of Lactobacillus on TNF-alpha production by peripheral blood mononuclear cells. Two strains increased TNF-alpha production; and the third one reduced cytokine levels. Disruption of rafts changed the immunomodulatory effect of the three strains. This is the first report on a potential role of rafts in lactobacilli-cell interaction.