CERELA   05438
CENTRO DE REFERENCIA PARA LACTOBACILOS
Unidad Ejecutora - UE
artículos
Título:
Disruption of Lipid Rafts Enhances the Effect of Lactobacilli on the Production of Tumor Necrosis Factor - Alpha in Mononuclear Blood Cells
Autor/es:
MARIO SORIA, MÓNICA MECHOUD, ANGELA MARTÍN DE QUEVEDO, GRACIELA FONT DE VALDEZ AND ANA V. RODRIGUEZ
Revista:
BIOSCIENCE, BIOTECHNOLOGY AND BIOCHEMISTRY
Editorial:
Japan Society for Bioscience, Biotechnology, and Agrochemistry
Referencias:
Lugar: Tokio, Japón; Año: 2008 vol. 72 p. 3293 - 3293
ISSN:
0916-8451
Resumen:
Disruption of Lipid Rafts Enhances the Effect of Lactobacilli on the Production of Tumor Necrosis Factor-Alpha in Mononuclear Blood Cells                                                              Mario SORIA1), Mónica MECHOUD1), Angela MARTIN DE QUEVEDO2), Graciela FONT DE VALDEZ1) and Ana V. RODRIGUEZ1) 1) Center of Reference for Lactobacilos (CERELA-CONICET) 2) Laboratorio Quevedo    We investigated, to determine whether disruption of lipid rafts would influence the effect of three selected strains of Lactobacillus on TNF-alpha production by peripheral blood mononuclear cells. Two strains increased TNF-alpha production; and the third one reduced cytokine levels. Disruption of rafts changed the immunomodulatory effect of the three strains. This is the first report on a potential role of rafts in lactobacilli-cell interaction.