CERELA   05438
CENTRO DE REFERENCIA PARA LACTOBACILOS
Unidad Ejecutora - UE
artículos
Título:
Effects of short-term mild calorie restriction diet and renutrition with
Autor/es:
GAUFFIN CANO, P; VAN NIEUWENHOVE, C.; CHAILA, Z; BAZÁN, C; GONZÁLEZ, S.
Revista:
NUTRITION
Editorial:
ELSEVIER SCIENCE INC
Referencias:
Año: 2009 vol. 25 p. 322 - 329
ISSN:
0899-9007
Resumen:
Objective: The adaptation of an organism to a calorie-restricted diet is characterized by metabolic,
endocrine, and immunologic changes. The objective of this study was to determine, in a mouse
model, the changes in serum leptin levels in response to short-term mild calorie-restricted and
renutrition diets using different ruminant milks.
endocrine, and immunologic changes. The objective of this study was to determine, in a mouse
model, the changes in serum leptin levels in response to short-term mild calorie-restricted and
renutrition diets using different ruminant milks.
The adaptation of an organism to a calorie-restricted diet is characterized by metabolic,
endocrine, and immunologic changes. The objective of this study was to determine, in a mouse
model, the changes in serum leptin levels in response to short-term mild calorie-restricted and
renutrition diets using different ruminant milks.
Methods: Weaned Swiss albino mice were fed with a mild calorie-restricted diet for 12 d, after
which they were renourished with cow, goat, sheep, or buffalo milk for 7 d. Body, thymus, and
spleen weights and biochemical, hematologic, and endocrine parameters were evaluated.
which they were renourished with cow, goat, sheep, or buffalo milk for 7 d. Body, thymus, and
spleen weights and biochemical, hematologic, and endocrine parameters were evaluated.
Weaned Swiss albino mice were fed with a mild calorie-restricted diet for 12 d, after
which they were renourished with cow, goat, sheep, or buffalo milk for 7 d. Body, thymus, and
spleen weights and biochemical, hematologic, and endocrine parameters were evaluated.
Results: The mild calorie restriction did not significantly modify insulin and leptin levels. The
renutrition diets increased insulin levels, being significant (P 0.05) only when buffalo and sheep
milks were used. Leptin concentrations increased in the control ad libitum (AD) group during the
assayed period. After the administration of cow and goat milks, lower leptin levels were observed
compared with the control AD group. All repletion diets significantly increased body, thymus, and
spleen weights; however, spleen weight did not reach the values observed in the control AD group.
Serum glucose and triacylglycerol levels increased after feeding with the renutrition diets. However,
serum cholesterol did not increase after the renutrition period. We observed a significant decrease
(P 0.05) in the leukocyte counts in calorie-restricted mice in comparison with AD mice; after the
renutrition period, the leukocyte count did not reach the values for the AD mice.
renutrition period, the leukocyte count did not reach the values for the AD mice.
milks were used. Leptin concentrations increased in the control ad libitum (AD) group during the
assayed period. After the administration of cow and goat milks, lower leptin levels were observed
compared with the control AD group. All repletion diets significantly increased body, thymus, and
spleen weights; however, spleen weight did not reach the values observed in the control AD group.
Serum glucose and triacylglycerol levels increased after feeding with the renutrition diets. However,
serum cholesterol did not increase after the renutrition period. We observed a significant decrease
(P 0.05) in the leukocyte counts in calorie-restricted mice in comparison with AD mice; after the
renutrition period, the leukocyte count did not reach the values for the AD mice.
renutrition period, the leukocyte count did not reach the values for the AD mice.
renutrition diets increased insulin levels, being significant (P 0.05) only when buffalo and sheep
milks were used. Leptin concentrations increased in the control ad libitum (AD) group during the
assayed period. After the administration of cow and goat milks, lower leptin levels were observed
compared with the control AD group. All repletion diets significantly increased body, thymus, and
spleen weights; however, spleen weight did not reach the values observed in the control AD group.
Serum glucose and triacylglycerol levels increased after feeding with the renutrition diets. However,
serum cholesterol did not increase after the renutrition period. We observed a significant decrease
(P 0.05) in the leukocyte counts in calorie-restricted mice in comparison with AD mice; after the
renutrition period, the leukocyte count did not reach the values for the AD mice.
renutrition period, the leukocyte count did not reach the values for the AD mice.
milks were used. Leptin concentrations increased in the control ad libitum (AD) group during the
assayed period. After the administration of cow and goat milks, lower leptin levels were observed
compared with the control AD group. All repletion diets significantly increased body, thymus, and
spleen weights; however, spleen weight did not reach the values observed in the control AD group.
Serum glucose and triacylglycerol levels increased after feeding with the renutrition diets. However,
serum cholesterol did not increase after the renutrition period. We observed a significant decrease
(P 0.05) in the leukocyte counts in calorie-restricted mice in comparison with AD mice; after the
renutrition period, the leukocyte count did not reach the values for the AD mice.
renutrition period, the leukocyte count did not reach the values for the AD mice.
The mild calorie restriction did not significantly modify insulin and leptin levels. The
renutrition diets increased insulin levels, being significant (P 0.05) only when buffalo and sheep
milks were used. Leptin concentrations increased in the control ad libitum (AD) group during the
assayed period. After the administration of cow and goat milks, lower leptin levels were observed
compared with the control AD group. All repletion diets significantly increased body, thymus, and
spleen weights; however, spleen weight did not reach the values observed in the control AD group.
Serum glucose and triacylglycerol levels increased after feeding with the renutrition diets. However,
serum cholesterol did not increase after the renutrition period. We observed a significant decrease
(P 0.05) in the leukocyte counts in calorie-restricted mice in comparison with AD mice; after the
renutrition period, the leukocyte count did not reach the values for the AD mice.
renutrition period, the leukocyte count did not reach the values for the AD mice.
milks were used. Leptin concentrations increased in the control ad libitum (AD) group during the
assayed period. After the administration of cow and goat milks, lower leptin levels were observed
compared with the control AD group. All repletion diets significantly increased body, thymus, and
spleen weights; however, spleen weight did not reach the values observed in the control AD group.
Serum glucose and triacylglycerol levels increased after feeding with the renutrition diets. However,
serum cholesterol did not increase after the renutrition period. We observed a significant decrease
(P 0.05) in the leukocyte counts in calorie-restricted mice in comparison with AD mice; after the
renutrition period, the leukocyte count did not reach the values for the AD mice.
renutrition period, the leukocyte count did not reach the values for the AD mice.
P 0.05) only when buffalo and sheep
milks were used. Leptin concentrations increased in the control ad libitum (AD) group during the
assayed period. After the administration of cow and goat milks, lower leptin levels were observed
compared with the control AD group. All repletion diets significantly increased body, thymus, and
spleen weights; however, spleen weight did not reach the values observed in the control AD group.
Serum glucose and triacylglycerol levels increased after feeding with the renutrition diets. However,
serum cholesterol did not increase after the renutrition period. We observed a significant decrease
(P 0.05) in the leukocyte counts in calorie-restricted mice in comparison with AD mice; after the
renutrition period, the leukocyte count did not reach the values for the AD mice.
renutrition period, the leukocyte count did not reach the values for the AD mice.
P 0.05) in the leukocyte counts in calorie-restricted mice in comparison with AD mice; after the
renutrition period, the leukocyte count did not reach the values for the AD mice.
Conclusion: This study suggests that a short-term change in diet with a relatively low body weight
loss does not significantly affect leptin concentrations in our mouse model. However, the assayed
milks could be effectively used as alternative milk sources for weight gain and for the improvement
of other metabolic parameters. © 2009 Published by Elsevier Inc.
loss does not significantly affect leptin concentrations in our mouse model. However, the assayed
milks could be effectively used as alternative milk sources for weight gain and for the improvement
of other metabolic parameters. © 2009 Published by Elsevier Inc.
This study suggests that a short-term change in diet with a relatively low body weight
loss does not significantly affect leptin concentrations in our mouse model. However, the assayed
milks could be effectively used as alternative milk sources for weight gain and for the improvement
of other metabolic parameters. © 2009 Published by Elsevier Inc.