CERELA   05438
CENTRO DE REFERENCIA PARA LACTOBACILOS
Unidad Ejecutora - UE
artículos
Título:
Isoflavone-supplemented soy yogurt associated with resistive physical exercise increase bone mineral density of ovariectomized rats
Autor/es:
GILBERTO EIJI SHIGUEMOTO; ELIZEU ANTONIO ROSSI; VILMAR BALDISSERA; CECÍLIA HELENA GOUVEIA; GRACIELA MARÍA FONT DE VALDÉZ
Revista:
MATURITAS
Referencias:
Año: 2007 vol. 57 p. 261 - 270
ISSN:
0378-5122
Resumen:
OBJECTIVE: To determine the effects produced by the ingestion of a fermented
soy product (soy yoghurt), supplemented with isoflavones and associated with a
resistive exercise program, on the bone metabolism of mature ovariectomized
(Ovx) and sham-ovariectomized (sham-Ovx) rats. METHODS: A total of 56 rats
were used. They were divided into 2 sedentary control groups, the Ovx control
group (C-Ovx) and the sham-Ovx control group (C-Sovx), each with 7 sedentary
animals, and 2 treated groups, Ovx and sham-Ovx, with 21 animals each. These
two treated groups were subdivided into three subgroups of seven animals each,
which received the following treatments: consuming the soy yoghurt+sedentary,
only subjected to resistive exercise, and consuming the soy yoghurt+resistive
exercise. Both the program of resistive exercise and the consumption of soy
yoghurt (at 3 mL/(kg body weight day)) continued for 12 weeks. The soy
yoghurt was supplemented with isoflavones at 50mg/100g of product. The
animals were sacrificed and their right-side femurs and tibias removed and
assessed for bone mineral density (BMD). The alkaline phosphatase activity
(AP) was determined in the blood serum. RESULTS: There was a significant
increase in both femur and tibia BMD values and in serum alkaline phosphatase
activity in all the treated subgroups, compared with the control groups (p<0.05).
CONCLUSION: The ingestion of the soy yoghurt supplemented with
isoflavones was capable of preventing a loss of bone mass in Ovx rats and of
increasing bone mass in sham rats, whilst the resistive exercise program was
effective in augmenting the bone mass in sham and Ovx rats.