CENTRO DE REFERENCIA PARA LACTOBACILOS
Unidad Ejecutora - UE
Administration of Lactobacillus fermentum CRL1446 increases intestinal feruloyl esterase activity in mice
ABEIJÓN MUKDSI, C; GAUFFIN CANO, PAOLA; GONZALEZ, S; MEDINA, R
LETTERS IN APPLIED MICROBIOLOGY
WILEY-BLACKWELL PUBLISHING, INC
Año: 2011 vol. 54 p. 18 - 18
Aims: To evaluate the effect of oral administration of Lactobacillus fermentum CRL1446 on the intestinal feruloyl esterase (FE) activity and oxidative status of mice. Methods and Results: Adult Swiss albino mice received Lact. fermentum CRL1446 at the doses 107 and 109 cells per day per mouse for 2, 5, 7 and 10 days. Intestinal FE activity, intestinal microbiota counts, plasmatic thiobarbituric acid-reactive substances (TBARS) percentage and glutathione reductase (GR) activity were determined. Mice that received Lact. fermentum CRL1446 at the dose 107 cells day-1 for 7 days showed a 2-fold increase in total intestinal FE activity, compared to the non-treated group. In large intestine content, FE activity increased up to 6.4 times. No major quantitative changes of colonic microbiota were observed in treated animals. Administration of this strain produced a 30-40% decrease in the basal levels of plasmatic TBARS, and a 2-fold increase in GR activity from day 5 of feeding with both doses. Conclusions: Oral administration of Lact. fermentum CRL1446 to mice increases total intestinal FE activity, decreases the basal percentage of plasmatic lipoperoxides and increases GR activity. Significance and Impact of Study: Lact. fermentum CRL1446 could be orally administered as a dietary supplement or functional food for increasing the intestinal FE activity to enhance the bioavailability of ferulic acid, thus improving oxidative status.