CENTRO DE REFERENCIA PARA LACTOBACILOS
Unidad Ejecutora - UE
Importance of IL-10 modulation by probiotic microorganisms in gastrointestinal inflammatory diseases
DE MORENO DE LEBLANC, A.; DEL CARMEN, S.; ZURITA-TURK, M.; SANTOS ROCHAT, C.; VAN DE GUCHTE, M.; AZEVEDO, V.; MIYOSHI, A.; LEBLANC, J. G.
Hindawi Publishing Corporation
Lugar: New York; Año: 2011 vol. 2011 p. 1 - 1
Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that are naturally present in many foods andpossess a wide range of therapeutic properties. The aim of this paper is to present an overview of the current expanding knowledgeof one of the mechanisms by which LAB and other probiotic microorganisms participate in the prevention and treatment ofgastrointestinal inflammatory disease through their immune-modulating properties. A special emphasis will be placed on thecritical role of the anti-inflammatory cytokine IL-10, and a brief overview of the uses of genetically engineered LAB that producethis important immune response mediator will also be discussed. Thus, this paper will demonstrate the critical role that IL-10plays in gastrointestinal inflammatory diseases and how probiotics could be used in their treatment.