CENTRO DE REFERENCIA PARA LACTOBACILOS
Unidad Ejecutora - UE
Coagulation activation in an experimentalpneumonia model in malnourished mice
ZELAYA HORTENSIA; HARO CECILIA; LAIÑO JONATHAN; ALVAREZ SUSANA; AGÜERO GRACIELA
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS
Lugar: Otawa; Año: 2011 vol. 89 p. 41 - 41
Malnutrition induces a decrease in immunity that affects the ability of the organism to deal with an infectious challenge. The clotting system is considered a branch of immunity and its activation is important in the pathogenesis of an infectious disease. This work was conducted to determine coagulation modifications in malnourished hosts before and during infection. Weaned mice were malnourished via a protein-free diet. Well-nourished control mice (WNC) consumed abalanced conventional diet. Malnourished mice (MN) and WNC were challenged intranasally with Streptococcus pneumoniae. Blood, bronchoalveolar lavages (BAL), and lung samples were taken at different times post infection. The results were that MN showed altered hemostatic tests and fibrin(ogen) deposits in the lung. Thus, an increase in thrombin?antithrombin complexes (TATc) in plasma and BAL was observed. In the MN group, infection induced a rise in TATc inplasma and BAL and increased plasma fibrinogen and fibrin(ogen) deposits in the lung. A decrease in activated protein C and antithrombin in BAL and an early decrease followed by an increase in plasma Factor VIII were also observed. Thus, malnourishment induced a procoagulant state increased by infection. This is the first work that presents results of an ex-haustive study of coagulation in malnourished hosts before and during an infection.