CERELA   05438
CENTRO DE REFERENCIA PARA LACTOBACILOS
Unidad Ejecutora - UE
artículos
Título:
Adjuvant effect of a probiotic fermented milk in the protection against Salmonella enteritidis serovar Typhimurium infection
Autor/es:
DE MORENO DE LEBLANC ALEJANDRA; MALDONADO GALDEANO CAROLINA; DOGI, CECILIA; CARMUEGA, ESTEBAN; WEILL, RICARDO; PERDIGĂ“N, GABRIELA.
Revista:
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
Editorial:
BIOLIFE SAS
Referencias:
Año: 2010 vol. 23 p. 1235 - 1235
ISSN:
0394-6320
Resumen:
Probiotics may offer protection against Salmonella enteritidis serovar Typhimurium infection via different mechanisms. The aim of this study was to investigate, using mouse models, the effect of the administration of fermented milk containing the probiotic bacteria L. casei DN- 114 001 in the protection against Salmonella enteritidis serovar Typhimurium when this product is administered continuously before and after infection or only post infection. The adjuvant effect of this probiotic fermented milk (PFM) against S. Typhimurium was also evaluated in newborn mice, whose mothers received the PFM during the suckling period or their offspring after weaning. The results obtained showed that PFM administration afterSalmonella enteritidis serovar Typhimurium infection via different mechanisms. The aim of this study was to investigate, using mouse models, the effect of the administration of fermented milk containing the probiotic bacteria L. casei DN- 114 001 in the protection against Salmonella enteritidis serovar Typhimurium when this product is administered continuously before and after infection or only post infection. The adjuvant effect of this probiotic fermented milk (PFM) against S. Typhimurium was also evaluated in newborn mice, whose mothers received the PFM during the suckling period or their offspring after weaning. The results obtained showed that PFM administration afterL. casei DN- 114 001 in the protection against Salmonella enteritidis serovar Typhimurium when this product is administered continuously before and after infection or only post infection. The adjuvant effect of this probiotic fermented milk (PFM) against S. Typhimurium was also evaluated in newborn mice, whose mothers received the PFM during the suckling period or their offspring after weaning. The results obtained showed that PFM administration afterSalmonella enteritidis serovar Typhimurium when this product is administered continuously before and after infection or only post infection. The adjuvant effect of this probiotic fermented milk (PFM) against S. Typhimurium was also evaluated in newborn mice, whose mothers received the PFM during the suckling period or their offspring after weaning. The results obtained showed that PFM administration afterS. Typhimurium was also evaluated in newborn mice, whose mothers received the PFM during the suckling period or their offspring after weaning. The results obtained showed that PFM administration after Salmonella infection was useful to decrease the severity of the infection. The best effect was obtained with continuous PFM administration. In the newborn mice model, PFM administration to the newborn mice after weaning showed the best effect against the pathogen. PFM administration to the mother during the suckling period was beneficial against this enterophatogen when their offspring did not receive probiotics after weaning. Continuous PFM administration to adult mice (before and after infection) was important to maintain the intestinal barrier and the immune surveillance in optimal conditions to diminish the pathway of entrance of Salmonella and the spread of this pathogen to deeper tissues. In the newborn mice model, it was observed that PFM administration to the offsprings after weaning or their mother during suckling period had a protective effect against Salmonella infection, however in the mice from mothers that received PFM during nursing were fed with PFM after weaning, we found a down regulated immune maturity, that was not protective against this infection.infection was useful to decrease the severity of the infection. The best effect was obtained with continuous PFM administration. In the newborn mice model, PFM administration to the newborn mice after weaning showed the best effect against the pathogen. PFM administration to the mother during the suckling period was beneficial against this enterophatogen when their offspring did not receive probiotics after weaning. Continuous PFM administration to adult mice (before and after infection) was important to maintain the intestinal barrier and the immune surveillance in optimal conditions to diminish the pathway of entrance of Salmonella and the spread of this pathogen to deeper tissues. In the newborn mice model, it was observed that PFM administration to the offsprings after weaning or their mother during suckling period had a protective effect against Salmonella infection, however in the mice from mothers that received PFM during nursing were fed with PFM after weaning, we found a down regulated immune maturity, that was not protective against this infection.Salmonella and the spread of this pathogen to deeper tissues. In the newborn mice model, it was observed that PFM administration to the offsprings after weaning or their mother during suckling period had a protective effect against Salmonella infection, however in the mice from mothers that received PFM during nursing were fed with PFM after weaning, we found a down regulated immune maturity, that was not protective against this infection.Salmonella infection, however in the mice from mothers that received PFM during nursing were fed with PFM after weaning, we found a down regulated immune maturity, that was not protective against this infection.
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