CERELA 05438
CENTRO DE REFERENCIA PARA LACTOBACILOS
Unidad Ejecutora - UE
artículos
Título:
Peroxisome proliferator-activated receptor pathways in diabetic rat decidua early after implantation: regulation by dietary polyunsaturated fatty acids
Autor/es:
GATTI, CINTIA ROMINA; JAWERBAUM, ALICIA; ROBERTI, SABRINA LORENA; HIGA, ROMINA; EVANGELINA, CAPOBIANCO
Revista:
REPRODUCTIVE BIOMEDICINE ONLINE
Editorial:
REPRODUCTIVE HEALTHCARE LTD
Referencias:
Año: 2022
ISSN:
1472-6483
Resumen:
Research Question: Are PPAR pathways and moieties involved in histotrophic nutrition altered in the decidua from diabetic rats? Can diets enriched in PUFAs administered during early postimplantation prevent these alterations? Are these dietary treatments able to improve morphological parameters in the fetus, decidua and placenta at a postplacentation stage? Design: Diabetes was induced by streptozotocin in Albino Wistar rats fed a standard diet or diets enriched in n3- or n6-PUFAs during early postimplantation. Decidual samples were collected on day 9 of pregnancy. Fetal, decidual and placental morphological parameters were evaluated on day 14 of pregnancy.Results: On gestation day 9, PPARδ levels showed no changes in the diabetic rat decidua compared to controls. PPARα levels and the expression of its target genes Aco and Cpt1 were reduced in the diabetic rat decidua. These alterations were prevented by the n6-PUFA-enriched diet. PPARγ levels, the expression of its target gene Fas, lipid droplet number and perilipin 2 and fatty acid binding protein 4 levels were increased in the diabetic rat decidua compared to controls. PUFAs-enriched diets prevented PPARγ increase, but not the increased lipid-related PPARγ targets. On gestation day 14, fetal growth and decidual and placental weight were reduced in the diabetic group, alterations prevented by the maternal diets enriched in PUFAs.Conclusion: When diabetic rats are fed diets enriched in n3- and n6-PUFAs during early postimplantation, PPAR pathways, lipid-related genes and proteins, lipid droplets and glycogen content in the decidua are modulated, probably influencing decidual histotrophic function and later feto-placental development.
