Improving bioactive and antibacterial performance by designed hybrid coatings of degradable magnesium implants.

CERE; ALDO R. BOCCACCINI; MERLO JULIETA; JOSEFINA BALLARRE

evento on line por COVID

Workshop; Updates in Bioabsorbable Metals 2020; 2020

Magnesium alloys are promising candidate materials for bio-absorbable fracture fixation devices; however, their fast corrosion in aqueous media generates hydrogen gas evolution, which causes pain and swelling. In this study, a hybrid biocompatible and bioactive coating system composed by a sol-gel silica based matrix with bioactive glass micro particles and silica-gentamicin (Si-G) nanoparticles was developed and applied through spray deposition. This coating system was intended to decrease the magnesium alloy degradation, but also to provide bioactive and antibacterial properties to the implant surface. The dual-coating system had the purpose of releasing gentamicin sulphate in two shocks in order to attack possible bacteria invasion at the time of implantation and potential remaining colonies after a period of time.