Crosslinked electrospun membranes based on SPIMA for tissue engineering applications

P.C. CARACCIOLO; A.A. ALDANA; M. POPOV; G.A. ABRAHAM

Porto Alegre

Workshop; 4° Encontro Internacional de Engenharia de Tecidos e Medicina Regenerativa; 2018

TERMIS AMERICA

In tissue engineering and regenerative medicine field, the mimicking of the extracellular matrix (ECM) is being widely studied to improve the cell adhesion, proliferation and differentiation. Among the techniques used to reproduce the EMC?s morphology, electrospinning has been intensively used to obtain nanofibrous structures from polymeric solutions, emulsions, suspensions or molten polymers. Soy protein isolate (SPI) electrospun mats have been studied for different biomedical application, such as wound dressing, tissue engineering, and drug delivery systems, among others. However, the high-water solubility of electrospun proteins limits their use; therefore, several strategies to tailor the SPI stability, such as chain crosslinking or blending have been explored.