Multiscale constitutive modelling for tissue engineering nanofibrous scaffolds

F. MONTINI BALLARIN; D. CABALLERO; S.A. URQUIZA

Mar del Plata

Simposio; XVI Latin-American Polymer Symposium (SLAP 2018) - XIV Iberoamerican Polymer Congress (CIP 2018),; 2018

Instituto de Ciencia y Tecnología en Materiales (INTEMA)

Mechanical modelling of scaffolds for tissue engineering emerges as a fundamental instrument in the development of synthetic extracellular matrices with biomimetic characteristics. It also plays an important role in the scaffold design and prediction of its behavior in vivo. This permits to save time and experimental essays in the laboratory, and predict how the different variables will affect the scaffold final behavior. Therefore, multiscale and structured constitutive models present an advantage against phenomenological ones, since they allow linking the materials microscopic properties with macroscopic parameters while improving the scaffold configuration to obtain the seeked mechanical response1,2.The mechanical mismatch between the natural and synthetic tissue is one of the principal causes of scaffolds failure3. With this in mind, this work presents a multiscale constitutive model oriented to predict and optimize the scaffolds behavior in order to obtain a good biomimetic mechanical response.