Antimicrobial electrospun nanocomposite membranes for dental applications

S. RAPUNTEAN; G. FURTOS; G.A. ABRAHAM; G. RIVERO

Valencia

Conferencia; International Conference on Nanotechnology Applications, NANOTEC2016; 2016

CSIC, GEP

In this work, porous matrices composed of PCL and nHAp loaded with amoxicillin (AMX) were prepared as material designed for biomedical applications. Different electrospun antibiotic-loaded nanocomposites were obtained by varying AMOX/nHAp ratio, to produce a series of PCL/AMOX, PCL/nHAp and PCL/AMOX/nHAp matrices.The structural, morphological, surface and thermal properties were characterized by using X-ray diffraction (XRD), scanning electron microscopy (SEM, EDAX), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), contact angle measurements, AMX release. The antimicrobial activity of the AMX-loaded membranes was tested with four bacterial strains: Staphylococcus aureus (ATCC 6538P), Staphylococcus aureus (collection strain), Salmonella typhimurium (ATCC 14028) and Micrococcus luteus (lizodeikticus). Extensive mineralization in simulated body fluid (SBF) was evidenced by SEM/EDX analysis after 21 days. The results reveal that these electrospun nanocomposite amoxicillin-loaded scaffolds could be a promising antimicrobial biodegradable material for biomedical application.