Ionic Dissolution Products from a Lithium-doped 45S5 Bioactive Glass Promotes Angiogenesis

HARO DURAND L; GABRIELA E. VARGAS,; VERA MESONES, R;; GORUSTOVICH A

Amsterdam Netherlands.

Workshop; 5th International Meeting on Angiogenesis; 2014

University Medical CenterAmsterdam, The Netherlands,

One of the main limitations to vascularized tissue regenerative medicine is the difficulty in achieving the rapid neovascularization needed for the transportation and exchange of oxygen, nutrients, growth factors and cells that take part in the process of tissue repair and/or regeneration. As it has been established that lithium (Li) may perform functions in angiogenesis, the controlled and localized release of Li ions from biomaterials could be expected to provide a promising therapeutic alternative for repairing and regenerating tissues that require a high degree of vascularization, e.g. bone tissue. The aim of this study was to assess the angiogenic effects of the ionic dissolution products from bioactive glasses in the SiO2-CaO-Na2O-P2O5 (45S5) system and 45S5 modified with 5% Li2O (45S5.5Li). The ionic dissolution products were obtained by incubating 1% w/v bioactive glass particles (