INIBIOLP   05426
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE LA PLATA "PROF. DR. RODOLFO R. BRENNER"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Frequently-used agrochemicals lead to functional and morphological sperm alterations in rats
Autor/es:
HURTADO DE CATALFO GRACIELA; ASTIZ MARIANA; TACCONI DE ALANIZ MARÍA J.; MARRA CARLOS ALBERTO
Lugar:
San Miguel de Tucumán, Tucumán, Argentina
Reunión:
Congreso; XLV Reunión Anual de SAIB (Sociedad Argentina de Investigación Bioquímica y Biología Molecular); 2009
Institución organizadora:
SAIB (Sociedad Argentina de Investigación en Bioquímica y Biología Molecular)
Resumen:
A reproductive health decline has been incremented in the last two decades. It seems to be a multi-factorial event that involves genetic and environmental factors. Nowadays, it is well established the relationship between male infertility and oxidative-nitrative stress induced by pollutants. Previous works of our lab demonstrated that low-doses of widely used pesticides seriously impaired the testicular antioxidant defense system. In this work we treated male Wistar rats sub-chronically (5 weeks) with low doses (1/250 LD50) of a mixture of zineb (Z), glyphosate (G) and dimethoate (D). Alterations in mature sperm vitality and morphology were evaluated. In the group treated with the mixture of Z, G and D the percentage of vital mature sperm decreased. Concomitantly, agonic and dead sperm increased compared with controls. The treated group showed a 20 % decrease in acrosomal reaction ability while fructose and free tiols were increased by 30 and 40 %, respectively. The number of morphologic alterations at sperm head, body and tail were also higher in the treated group. Taking into account the low doses that provoked these sperm alterations, environmental pollution with agrochemicals may play a key role, increasing fertility abnormalities since 1980’s.