INIBIOLP   05426
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE LA PLATA "PROF. DR. RODOLFO R. BRENNER"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Analysis of fatty acid binding proteins (FABP) of parasitic cestodes as novel therapeutic targets
Autor/es:
MATÍAS PÉREZ; MARA ROSENZVIT; JORGE L. PÓRFIDO; BETINA CÓRSICO; JULIAN A. BELGAMO; GISELA R. FRANCHINI
Lugar:
Montevideo
Reunión:
Workshop; Drug Discovery for Neglected Diseases and Malaria; 2016
Resumen:
The main goal of this project is to contribute to the control of endemic diseases caused by cestodes parasites like hydatidosis and cysticercosis, endemic zoonosis in our region that are part of the diseases considered neglected by WHO, for which the repertoire of therapeutic drugs is extremely limited. Due to the scarcity of available anthelmintic drugs and the possible emergence of resistance, the discovery of new drugs is mandatory. Our group has characterized a number of molecules that may play important roles in nutrient acquisition, attenuation of host?s immune response and development of these parasites. We will evaluate specific parasite molecules as new therapeutic targets using bioinformatics, molecular biology, biochemistry and biophysical methods.