INIBIOLP   05426
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE LA PLATA "PROF. DR. RODOLFO R. BRENNER"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Copper, ceruloplasmin, and oxidative stress biomarker levels in human neurodegenerative disorders
Autor/es:
MARRA, CARLOS ALBERTO; ARNAL, NATHALIE; CRISTALLI, DIANA; TACCONI DE ALANIZ, MARÍA JOSEFA
Lugar:
Villa Carlos Paz, Córdoba
Reunión:
Congreso; 44 Reunión Nac. Soc. Argentina de Invest. Bioqca. y Biología Molecular (SAIB); 2008
Institución organizadora:
SAIB
Resumen:
Cu imbalance and oxidative stress (OS) are documented in brain tissue of Alzheimer patients (AD). However, their utility as prognostic parameters in peripheral blood is still poorly understood. We studied the levels of thiobarbituric acid reactive substances (TABRS), nitrate + nitrite [NOx], protein carbonyls (PCs), total glutathione (GSH), a-tocopherol (Toc), antioxidant enzymes, Cu, Se, Zn, and ceruloplasmine (CRP) in plasma and erythrocytes from AD, Parkinson (PD) and vascular dementia patients (VD). Results were compared with first order relatives (R) and a control population. All OS markers were altered in AD, PD and VD compared with the corresponding control group. Superoxide dismutase, GSH-reductase, and catalase activities in erythrocytes, TBARS, PCs, and [NOx] were increased; while GSH and Toc in AD, PD and VD were decreased. Cu level was increased in severe AD and PD patients, and in all stages of VD. R of AD and VD also exhibited an increased [Cu] not associated to substantial and clear alterations in OS biomarkers. CRP was increased only in VD samples. We conclude that peripheral OS biomarkers should be poorly discriminating indexes for the screening of the type and severity of neurodegenerative disorders; however, the CRP/Cu ratio may be useful in estimating the progression from a sub-clinical condition to a symptomatological illness, especially in R of VD.