INIBIOLP 05426
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE LA PLATA "PROF. DR. RODOLFO R. BRENNER"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
New FABPs in Echinococcus spp. More pieces for a difficult to solve puzzle
Autor/es:
PORFIDO, J; FRANCHINI G; BREHM K; B. CÓRSICO
Lugar:
La Plata
Reunión:
Congreso; 8th International Conference on Lipid Binding Proteins (8ICLBP); 2013
Institución organizadora:
LBPS
Resumen:
Different species of the genus Echinococcus are pathogenic for humans and domestic animals, being E. granulosus and E. multilocularis the most representative. These parasites, like other cestodes, cannot synthesise most of their lipids de novo and therefore must obtain these nutrients from their hosts. Two fatty acid binding proteins (FABPs) had been described so far in E. granulosus: EgFABP1 and EgFABP2. However, since genomic data became available, other members of this family have been reported, both in E. granulosus and E. multilocularis. In this work, we show that at least four FABP genes seem to be transcribed in E. multilocularis, and also that the transcription would be different in different tissues or conditions of the parasite. Preliminary results have also shown that E. multilocularis? FABPs would be expressed in the tegument, i.e. the surface through which the parasite absorbs its nutrients and the one that is in direct contact with the hydatid fluid. An attempt to silence the expression of FABPs in E. multilocularis primary cells is also exposed.
