Unique functions of Intestinal FABPs

CORSICO, B; STORCH J

Fatty Acid Binding Proteins

Transworld Research Network

Año: 2009; p. 128 - 140

Intestinal FABP (IFABP) and liver FABP (LFABP) are homologous proteins expressed at high levels in intestinal absorptive cells, and bind preferentially fatty acids. Their specific functions have remained elusive. Both appear to be involved in the trafficking of their ligands within the cytosol, while LFABP has been shown to function, as well, in the regulation of nuclear transcription factor activity via ligand-dependent translocation to the nucleus.