INIBIOLP   05426
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE LA PLATA "PROF. DR. RODOLFO R. BRENNER"
Unidad Ejecutora - UE
capítulos de libros
Título:
Neuroendocrine system and aging: growth hormone, thyroid stimulating hormone, prolactin and insulin.
Autor/es:
SONNTAG WILLIAM E; HEREÑÚ CLAUDIA B; GOYA RODOLFO G
Libro:
New Encyclopedia of Neuroscience
Editorial:
Elsevier Science and Tech
Referencias:
Lugar: New York; Año: 2008;
Resumen:
Animals exhibit predictable and progressive impairments in a number of physiological processes over time and alterations in hormones that have a trophic and integrative role in maintaining tissue function(e.g thyroid stimulating hormone, prolactin, growth hormone, insulin-like growth factor-1 and its related hormone, insulin) likely contribute to the aging phenotype. Withdrawal of  trophic support mimics some of the phenotypes observed in aging animals and humans, and hormone replacement therapy improves function and, in some cases, increases lifespan. These studies provide compelling data that age-related alterations within the hypothalamic-pituitary axis regulate functional changes with age, age-related pathology and eventually lifespan.