INIBIOLP   05426
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE LA PLATA "PROF. DR. RODOLFO R. BRENNER"
Unidad Ejecutora - UE
artículos
Título:
Citrus reticulata peel oil inhibits non-small cell lung cancer cell proliferation in culture and implanted in nude mice.
Autor/es:
GARCÍA DE BRAVO, MARGARITA; RODENAK-KLADNIEW, BORIS; GARCÍA DE BRAVO, MARGARITA; RODENAK-KLADNIEW, BORIS; CRESPO, R.; MASSONE, ADRIANA; CRESPO, R.; MASSONE, ADRIANA; POLO, MÓNICA; CASTRO, MARÍA AGUSTINA; POLO, MÓNICA; CASTRO, MARÍA AGUSTINA
Revista:
Food & Function
Editorial:
Royal Society of Chemistry
Referencias:
Año: 2018 vol. 9 p. 2290 - 2299
ISSN:
2042-6496
Resumen:
Non-small cell lung cancer (NSCLC) accounts for most cases of lung cancer. The peel oil of mandarin Citrus reticulata Blanco cv. Dancy (MPO) is a natural source of essential oils and carotenoids. Volatile and non-volatile lipid compounds were characterized by chromatographic methods. We demonstrate that MPO causes a dose-dependent growth inhibition of NSCLC model cells (A549) in culture and tumour growth in vivo of these same cells implanted in nude mice fed with MPO-supplemented diets. MPO induced cell cycle arrest mainly at the G0/G1 phase and reduced the amount of membrane-bound Ras protein along with apoptosis induction. No toxicological effect was found in liver parameters analysed in treated mice and histopathological analyses of their organs were off any morphological changes. In conclusion, the data suggest that MPO possesses significant antitumor activity without causing systemic toxicity, rendering it a useful tool as a functional food supplement.