Cytotoxic effects of essential oils from four Lippia alba chemotypes in human liver and lung cancer cell lines

CICCIÓ, JOSÉ F.; RODENAK-KLADNIEW, BORIS; POLO, MÓNICA; GALLE, MARIANELA; CRESPO, ROSANA; GARCÍA DE BRAVO, MARGARITA; CASTRO, MARÍA AGUSTINA; MONTERO-VILLEGAS, SANDRA; CICCIÓ, JOSÉ F.; RODENAK-KLADNIEW, BORIS; POLO, MÓNICA; GALLE, MARIANELA; CRESPO, ROSANA; GARCÍA DE BRAVO, MARGARITA; CASTRO, MARÍA AGUSTINA; MONTERO-VILLEGAS, SANDRA

JOURNAL OF ESSENTIAL OIL RESEARCH

ALLURED PUBL CORP

Año: 2018 p. 1 - 15

1041-2905

ABSTRACT Essential oils (EOs) from aromatic plants contain molecules that can interfere with diseases suchas cancer and are considered attractive because of their widespread use, good bioavailability, lowtoxicity and affordable cost. EOs from Lippia alba (LaEOs) manifest intraspecific chemical differencesin its composition ? defined as chemotypes ? and is notable for the chemical diversity of theirvolatile secondary metabolites. We evaluated LaEOs chemotypes cytotoxicity on human cancerculture cells and investigated the mechanisms involved in tagetenone (ta) chemotype cytotoxicity.It exhibited selective cytotoxicity against HepG2 and A549 cells. The mechanism involved cell cyclearrest and apoptosis induction. Tagetenone chemotype (LaEOta) treatment caused 3-hydroxy-3-methylglutaryl-coenzyme A reductase decrease and profound cholesterogenesis inhibition withfarnesyl pyrophosphate redirection towards other end products, such as ubiquinone. This workcontributes to a clearer understanding of mechanisms of action of LaEOta, thus suggesting that theuse of that tagetenone chemotype could provide significant health benefits as a chemopreventiveand/or chemotherapeutic agent.