Role of cortisol in inflammation triggered by macrophages exposition to modified LDL

GRASA, MARÍA DEL MAR; ESTEVE, MONTSERRAT; JOSE GULFO; GARDA, H. A.; GONZALEZ MARINA CECILIA; RAMELLA NAHUEL; JUAN D. TOLEDO; LEDDA, ANGELO; DÍAZ LUDOVICO IVO

Data in Brief-Journal

Elsevier

Año: 2016 vol. 8 p. 251 - 257

This brief date article summarizes experimental evidence upon a protective and specific effect of cortisol when THP cells are loaded with acetylated or oxidized low density lipoprotein (LDL).We also show time-dependent effect on gene expression related to inflammation and cholesterol deposition in lipid-loaded human macrophages. Data show that the degree of oxidative damage of LDL (Ox-LDL) is related to cellular survival. The data herein provided are directly related to the article ?Decreased OxLDL uptake and cholesterol efflux in THP1 cells elicited by cortisol and by cortisone through 11β-hydroxysteroid dehydrogenase type 1?