INIBIOLP 05426
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE LA PLATA "PROF. DR. RODOLFO R. BRENNER"
Unidad Ejecutora - UE
artículos
Título:
Loss of NeuN immunoreactivity in rat spinal cord neurons during aging
Autor/es:
EL PORTIANSKY; CG BARBEITO; EJ GIMENO; GO ZUCCOLILLI; RODOLFO GUSTAVO GOYA
Revista:
Experimental Neurology
Editorial:
Academic Press
Referencias:
Lugar: United States; Año: 2006 vol. 202 p. 511 - 512
ISSN:
0014-4886
Resumen:
A morphologic study of the impact of aging on neuron marker expression was performed in different segments of the rat spinal cord. Spinal cord specimens from young (5 months), middle-aged (12 months) and senile (32 months) female rats were assessed. We found a complete loss of neuron-specific nuclear protein (NeuN) immunoreactivity in cervical, thoracic and lumbar segments of the senile animals whereas neuron-specific enolase (NSE) immunoreactivity was comparable in young and senile rats. These findings in otherwise morphologically well preserved spinal cord neurons are of interest and reveal that NeuN may not be a reliable marker to identify neurons in the spinal cord of aging rats.
