INIBIOLP 05426
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE LA PLATA "PROF. DR. RODOLFO R. BRENNER"
Unidad Ejecutora - UE
artículos
Título:
Geraniol and simvastatin show a synergistic effect on a human hepatocarcinoma cell line.
Autor/es:
POLO, M.P.; CRESPO, R; DE BRAVO, MG
Revista:
CELL BIOCHEMISTRY AND FUNCTION
Editorial:
JOHN WILEY & SONS LTD
Referencias:
Año: 2011 vol. 29 p. 452 - 458
ISSN:
0263-6484
Resumen:
Simvastatin is a competitive inhibitor of HMG-CoA reductaseactivity whereas geraniol is a monoterpene with multiplepharmacologic effects on mevalonate metabolism. Both of theminhibit growth and proliferation of many cell lines. The presentstudy was designed to determine the action of geraniol, incombination with simvastatin, by assessing their effects in vitro onhuman hepatoma cell line (Hep G2). The treatment of Hep G2 cellswith concentrations of simvastatin or geraniol that did not inhibitcell proliferation (5 μM simvastatin and 50 μM geraniol) resulted ina significant inhibition of cell proliferation. We also examined theeffect of simvastatin, geraniol and the combination of both of themon the biosynthesis of lipids from [14C]-acetate. Our resultsdemonstrated that the combination of simvastatin and geraniolsynergistically inhibited cholesterol biosynthesis and proliferation ofHep G2 cell line, contributing to understand the action of acomponent of essential oils targeting a complex metabolic pathwaywhich would improve the use of drugs or their combination in thefight against cancer and/o cardiovascular diseases.
