Biodegradable polyester networks including hydrophilic groups favor BMSCs differentiation and can be eroded by macrophage action

OBERTI TG; FERNANDEZ JM, VIKINGSSON L, GÓMEZ RIBELLES JL, CORTIZO AM

POLYMER DEGRADATION AND STABILITY

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2016 vol. 130 p. 38 - 46

0141-3910

The aim of this study is to show that introducing a small fraction of hydrophilic groups into a hydrophobicpolyester favor the macrophage activity by accelerating the degradation action in aqueous media.It is also seen that differentiation of MSCs cultured in monolayer towards bone in specific differentiationmedia is favored in these materials with respect to the corresponding pristine polyesters. Polymernetworks based in polycarpolactone or poly(L-lactide) and containing a small fraction of poly(-hydroxyethyl acrylate) have been synthesized. Degradation kinetics in vitro was monitored by mass lossand swelling capacity of the polymer network in good solvents, the later as representative of chaincleavage. Hydrolytic and enzymatic degradation is accelerated by the inclusion of poly(hydroxyethylacrylate) blocks in the network. Macrophages were cultured on the surface of the network films, showingits capacity to erode the material surface but also to accelerate bulk degradation. Bone marrowmesenchymal stem cells were cultured in monolayer on the membranes in osteogenic media, showing anincrease of specific markers expression in comparison to pristine polyesters.