Reaction between 7,8-dihydropterins and hydrogen peroxide under physiological conditions

M. LAURA DÁNTOLA, TOBIAS M. SCHULER, M. PAULA DENOFRIO, MARIANA VIGNONI, ALBERTO L. CAPPARELLI, CAROLINA LORENTE, ANDRÉS H. THOMAS

TETRAHEDRON

Elsevier

Año: 2008 vol. 64 p. 8692 - 8699

0040-4020

In vitiligo, a common skin disorder that produces white patches of depigmentation, 7,8-dihydropterins accumulate in the presence of high concentration of H2O2. In this work, we present a study of the reaction between 7,8-dihydropterins and H2O2. The rate of the reaction, as well as the products formed, strongly depend on the chemical structure of the substituents. Electron-donor groups as substituents are the most reactive derivatives and undergo oxidation of the pterin moiety. The corresponding bimolecular rate constants at 37 C in neutral aqueous solutions are reported. The biological implications of the results obtained are also discussed.2O2. In this work, we present a study of the reaction between 7,8-dihydropterins and H2O2. The rate of the reaction, as well as the products formed, strongly depend on the chemical structure of the substituents. Electron-donor groups as substituents are the most reactive derivatives and undergo oxidation of the pterin moiety. The corresponding bimolecular rate constants at 37 C in neutral aqueous solutions are reported. The biological implications of the results obtained are also discussed.2O2. The rate of the reaction, as well as the products formed, strongly depend on the chemical structure of the substituents. Electron-donor groups as substituents are the most reactive derivatives and undergo oxidation of the pterin moiety. The corresponding bimolecular rate constants at 37 C in neutral aqueous solutions are reported. The biological implications of the results obtained are also discussed.