Lipid peroxidation modifies the assembly of biological membranes "The lipid Whisker Model"

A. CATALA

FRONTIERS PHYSIOLOGY Membrane Physiology and Membrane Biophysics

EPFL - Innovation Square

Lugar: Lausanne; Año: 2016 vol. 5 p. 1 - 5

1664-042X

The aim of this opinion article is to point out the basic principles that modify the assembly of biological membranes during lipid peroxidation. With this objective in mind I describe: the structural and functional properties of membranes, the transport and diffusion of oxygen regulated by cholesterol and fatty acids; the ?Lipid Whisker Model? and finally I analyze the changes induced by lipid peroxidation in membrane structure and dynamics, both at the lipid and protein level. A number of reviews of lipid peroxidation have appeared in recent years, related to the kinetics and biology of lipid peroxidation products [1-5]. The analysis of lipid peroxidation products has been particularly important in the advancement of research in this field because of the complexity of product mixtures. I also discuss the effect of other membrane modifications, triggered by lipid peroxidation products and reducing sugars. In addition Garrec et al [6] have recently investigated the validity of the ?floating peroxyl radical? hypothesis by means of molecular modelling.