INIFTA   05425
INSTITUTO DE INVESTIGACIONES FISICO-QUIMICAS TEORICAS Y APLICADAS
Unidad Ejecutora - UE
artículos
Título:
Photodynamic inactivation induced by carboxypterin: a novel non toxic bactericidal strategy against staphylococcus aureus planktonic cells and biofilms
Autor/es:
MIÑÁN, A; LLORENTE, C; IPIÑA, A; THOMAS, A; FERNÁNDEZ LORENZO DE MELE, M; SCHILARDI, P
Revista:
BIOFOULING
Editorial:
TAYLOR & FRANCIS LTD
Referencias:
Lugar: Londres; Año: 2015 vol. 31 p. 459 - 468
ISSN:
0892-7014
Resumen:
Microbial related contamination is of major concern and can cause substantial economic losses. Photodynamic inactivation(PDI) has emerged as a suitable approach to inhibit microorganism proliferation. In this work, PDI induced by6-carboxypterin (Cap), a biocompatible photosensitizer (PS), was analyzed. The growth inhibition of Staphylococcusaureus exposed to artificial UV-A radiation and sunlight in the presence of Cap was investigated. After UV-A irradiation,50 μM Cap was able to decrease by three orders (with respect to the initial value) the number of S. aureus cells in earlybiofilms. However, this concentration was 500 times higher than that needed for eradicating planktonic cells. Importantly,under solar exposure, 100 μM Cap was able to suppress sessile bacterial growth. Thus, this strategy is able toexert a bactericidal effect on sessile bacteria and to eradicate planktonic cells by exposing the Cap-containing sample tosunlight.