INIFTA 05425
INSTITUTO DE INVESTIGACIONES FISICO-QUIMICAS TEORICAS Y APLICADAS
Unidad Ejecutora - UE
artículos
Título:
Discovery of anticonvulsant activity of abietic acid through application of linear discriminant analysis
Autor/es:
A. TALEVI; M.S. CRAVERO; EDUARDO ALBERTO CASTRO; L. BRUNO BLANCH
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Editorial:
Elsevier
Referencias:
Año: 2007 vol. 17 p. 1684 - 1690
ISSN:
0960-894X
Resumen:
Linear discriminant analysis was performed to derive discriminant functions based on 2D descriptors and capable of classifying anticonvulsant from non-anticonvulsant compounds. Through application in virtual screening of the discriminant function which performed best in the validation steps, abietic acid was identified as a potential new anticonvulsant agent. The anticonvulsant activity of abietic acid at 30 and 100 mg/kg was confirmed in the Maximal Electroshock Test, both orally and intraperitoneally.
