INIFTA   05425
INSTITUTO DE INVESTIGACIONES FISICO-QUIMICAS TEORICAS Y APLICADAS
Unidad Ejecutora - UE
artículos
Título:
Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties
Autor/es:
PASQUALONE M.; OBERTI T. G. ,; ANDREETTA A.; CORTIZO M. S.
Revista:
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
Editorial:
SPRINGER
Referencias:
Lugar: Berlin; Año: 2013 vol. 24 p. 1683 - 1692
ISSN:
0957-4530
Resumen:
Novel copolymers of vinyl acetate and dialkylfumarates, poly(VA-co-DRF) with R = isopropyl (DIPF) or octan-2-yl (DOF), were synthesized by radical copolymerization under microwave conditions. The products were characterized by 1H NMR and FTIR spectroscopies, size exclusion chromatography and differential scanning calorimetry. Based on these copolymers three membranes supported on polyvinyl alcohol were prepared and their morphology, swelling and mechanical properties were studied. The swelling kinetic was analyzed and interpreted in light of the Fick transport model, showing that the water transport occurs through a non-Fickian diffusion mechanism. The results show that the membrane prepared of poly(VA-co-DOF) exhibited excellent properties as potential platform for transdermal delivery system: they exhibited good tensile strength, moderated swelling and form thin and transparent films.