INIFTA   05425
INSTITUTO DE INVESTIGACIONES FISICO-QUIMICAS TEORICAS Y APLICADAS
Unidad Ejecutora - UE
artículos
Título:
Adhesin Contribution to Nanomechanical Properties of the Virulent Bordetella pertussis Envelope
Autor/es:
ARNAL, L; SERRA, DO; CATTELAN, N; CASTEZ, MF; VAZQUEZ, L; SALVAREZZA, RC; YANTORNO, OM; VELA, ME
Revista:
LANGMUIR
Editorial:
AMER CHEMICAL SOC
Referencias:
Lugar: Washington; Año: 2012 vol. 28 p. 7461 - 7469
ISSN:
0743-7463
Resumen:
Adherence to a biological surface allows bacteria to colonize and persist within the host and represents an essential first step in the pathogenesis of most bacterial diseases. Consequently, the physicochemical properties of the outer membrane in bacteria play a key role for attachment to surfaces and therefore for biofilm formation. Bordetella pertussis is a Gram-negative bacterium that colonizes the respiratory tract of humans, producing whooping cough or pertussis, a highly infectious disease. B. pertussis uses various adhesins exposed on its surface to promote cell-surface and cell−cell interactions. The most dominant adhesin function is displayed by filamentous hemagglutinin (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis dominant adhesin function is displayed by filamentous hemagglutinin (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis surface to promote cell-surface and cell−cell interactions. The most dominant adhesin function is displayed by filamentous hemagglutinin (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis dominant adhesin function is displayed by filamentous hemagglutinin (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis respiratory tract of humans, producing whooping cough or pertussis, a highly infectious disease. B. pertussis uses various adhesins exposed on its surface to promote cell-surface and cell−cell interactions. The most dominant adhesin function is displayed by filamentous hemagglutinin (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis dominant adhesin function is displayed by filamentous hemagglutinin (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis surface to promote cell-surface and cell−cell interactions. The most dominant adhesin function is displayed by filamentous hemagglutinin (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis dominant adhesin function is displayed by filamentous hemagglutinin (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis Bordetella pertussis is a Gram-negative bacterium that colonizes the respiratory tract of humans, producing whooping cough or pertussis, a highly infectious disease. B. pertussis uses various adhesins exposed on its surface to promote cell-surface and cell−cell interactions. The most dominant adhesin function is displayed by filamentous hemagglutinin (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis dominant adhesin function is displayed by filamentous hemagglutinin (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis surface to promote cell-surface and cell−cell interactions. The most dominant adhesin function is displayed by filamentous hemagglutinin (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis dominant adhesin function is displayed by filamentous hemagglutinin (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis respiratory tract of humans, producing whooping cough or pertussis, a highly infectious disease. B. pertussis uses various adhesins exposed on its surface to promote cell-surface and cell−cell interactions. The most dominant adhesin function is displayed by filamentous hemagglutinin (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis dominant adhesin function is displayed by filamentous hemagglutinin (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis surface to promote cell-surface and cell−cell interactions. The most dominant adhesin function is displayed by filamentous hemagglutinin (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis dominant adhesin function is displayed by filamentous hemagglutinin (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis (FHA). B. pertussis Tohama I wild-type (Vir+) strain and two defective mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis mutants, an avirulent (Vir−) and a FHA-deficient (FHA−) B. pertussis is a Gram-negative bacterium that colonizes the respiratory tract of humans, producing whooping cough or pertussis, a highly infectious disease. B. pertussis uses various adhesins exposed on its surface to promote cell-surface and cell−