INIFTA   05425
INSTITUTO DE INVESTIGACIONES FISICO-QUIMICAS TEORICAS Y APLICADAS
Unidad Ejecutora - UE
artículos
Título:
Reduction of the ?burst release? of copper ions from copper-based Intrauterine Devices (IUD) by organic inhibitors
Autor/es:
ALVAREZ, F; SCHILARDI, P; FERNÁNDEZ LORENZO DE MELE, M
Revista:
CONTRACEPTION
Editorial:
ELSEVIER SCIENCE INC
Referencias:
Año: 2012 vol. 85 p. 91 - 98
ISSN:
0010-7824
Resumen:
Background: The copper intrauterine device (IUD) is a contraceptive method that is based on the release of copper ions from a copper wire. Immediately after the insertion the dissolution of copper in the uterine fluid is markedly higher (“burst release”) than that necessary for the contraception action, leading to a variety of harmful effects. Study design: Pretreatments with organic compounds (thiourea (TU) and purine (PU), 10-4- 10-2 M concentration range, 1h and 3h immersion times) were tested. The degradation of copper with and without pretreatments in TU and PU solutions was analysed by conventional electrochemical techniques and surface analysis. Results: Pretreatments in PU solutions reduce the initial corrosion rate of copper in simulated uterine solutions, with inhibitory efficiencies (IE) that depend on the PU concentration and on the immersion time assayed. IE values higher than 98% for pretreatments with >10-3 M PU were found. Conversely, after TU-pretreatments a high copper release was measured. Conclusions: It was concluded that 10-3 M PU-pretreatment is a promising strategy able to reduce the “burst release” of copper and to ensure the contraceptive action.