CINDECA 05422
CENTRO DE INVESTIGACION Y DESARROLLO EN CIENCIAS APLICADAS "DR. JORGE J. RONCO"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Circonia Sulfatada como un eficaz catalizador para la Síntesis de 1H-3,4-Dihidro-2,3-Benzotiazinas 2,2-Dióxido Y 1,2,3,4-Tetrahidro-3,2-Benzotiazepinas 3,3-Dióxido
Autor/es:
LEANDRO SAMSIABARRENA; L.J.MENDEZ; A.S.CÁNEPA; C.E.QUINCOCES; M.G.GONZÁLEZ; R.D.BRAVO
Lugar:
Benalmadena- Málaga- España
Reunión:
Simposio; XXI SICAT; 2008
Institución organizadora:
FISOCAT
Resumen:
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La eficiencia de la circonia
sulfatada empleada como catalizador en la síntesis de benzotiazinas y
benzotiazepinas en fase líquida es comparada con otros catalizadores ácidos
homo y heterogéneos. La reacción se llevó a cabo en un sistema batch a reflujo
a temperaturas entre 35 y 115 oC. La SO4=/ZrO2
presentó buenos rendimientos para la muestra previamente calcinada a 500 oC
y posibilidades de regeneración de la actividad catalítica mediante un simple
tratamiento del material usado en reacción. Durante la etapa de calcinación el
catalizador fue analizado por Difracción de Rayos X, Adsorción de N2
y espectroscopía Raman.
El estudio
de estos compuestos orgánicos tiene una potencial aplicación farmacológica.
Palabras
clave: 2,3-benzotiazinas,
3,2-benzotiazepinas, sulfonilamidometilación intramolecular, circonia
sulfatada, catálisis ácida.
