CINDECA   05422
CENTRO DE INVESTIGACION Y DESARROLLO EN CIENCIAS APLICADAS "DR. JORGE J. RONCO"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
MULTICOMPONENT SYNTHESIS OF FLUORINATED HEXAHYDROPYRIMIDINES USING ENCAPSULATED HETEROPOLYACIDS AS CATALYTS
Autor/es:
V. PALERMO; A. SATHICQ; D.M. RUIZ; T. CONSTANTIEUX; J. RODRIGUEZ; P.G. VÁZQUEZ.; G.P. ROMANELLI
Lugar:
Paris
Reunión:
Jornada; JCO 2013 ? Journées de Chimie Organique; 2013
Resumen:
Since the rise of Green Chemistry, multicomponent reactions have gained great importance in organic synthesis, as well as the use of heterogeneous catalysis.[1,2] For this reason, the commercial heteropolyacids (KC and PC) were turned into heterogeneous catalyst by sol-gel technique.[3,4] As an illustration of the advantages in combining heterogeneous catalysis with multicompnent processes, the three-component synthesis of trifluoromethylated hexahydropyrimidines is carried out using Keggin (KCSiO2) and Preyssler (PCSiO2) heteropolyacids encapsulated in a silica framework as catalysts (Scheme 1). The synthesized compounds have promised bioactivity, due to the presence of the trifluoromethyl group.[5]
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