CINDECA   05422
CENTRO DE INVESTIGACION Y DESARROLLO EN CIENCIAS APLICADAS "DR. JORGE J. RONCO"
Unidad Ejecutora - UE
artículos
Título:
A suitable preparation of N-sulfonyl-1,2,3,4- tetrahydroisoquinolines and their ring homologs with a reusable Preyssler heteropolyacid as catalyst
Autor/es:
GUSTAVO P. ROMANELLI; DIEGO M. RUIZ; JUAN C. AUTINO; HÉCTOR E. GIACCIO
Revista:
MOLECULAR DIVERSITY
Editorial:
SPRINGER
Referencias:
Lugar: Amsterdam; Año: 2010 vol. 14 p. 803 - 803
ISSN:
1381-1991
Resumen:
The preparation of N-sulfonyl-1,2,3,4-tetrahydroisoquinolines, N-sulfonyl-2,3,4,5-tetrahydro-1H-2-benzazepines and N-sulfonyl-1,2,3,4,5,6-hexahydrobenzazocine was catalyzed by a Preyssler heteropolyacid, H14[NaP5W30 O110], (PA), supported on silica (PASiO240) with excellent yields by means of the Pictet–Spengler reaction of N-aralkylsulfonamides with s-trioxane. The reactions proceed with 0.5mol% of silica-supported catalyst in toluene at 70 ◦C. The catalyst can be recycled without appreciable loss of the catalytic activity.
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