CINDECA   05422
CENTRO DE INVESTIGACION Y DESARROLLO EN CIENCIAS APLICADAS "DR. JORGE J. RONCO"
Unidad Ejecutora - UE
artículos
Título:
Microwave-induced Synthesis of N-Substituted 1-Alkyl and 1-Aryl 3-Aminoisoquinolines
Autor/es:
CÁNEPA, A.S.; BRAVO R. D.; MENDEZ, L.J.; VILLALBA M.L.
Revista:
LETTERS IN ORGANIC CHEMISTRY
Editorial:
BENTHAM SCIENCE PUBL LTD
Referencias:
Lugar: Oak Park; Año: 2017 vol. 14 p. 8 - 8
ISSN:
1570-1786
Resumen:
Abstract: Background: Aminoisoquinolines are an important class of heterocyclic compounds. Thesecompounds present a wide range of pharmacological properties including antimalaric, anticonvulsantand anti-inflammatory. Although several preparation routes may be found in the literature for the preparationof these compounds, many of these methods present difficulties, including laborious isolationmethods, drastic conditions and extended reaction times.Methods: The synthesis of N-substituted 1-alkyl and 1-aryl- 3-aminoisoquinolines is developed throughthe reaction of 2-acylphenylacetonitriles with amines under microwave irradiation conditions. The reactionswere performed in ethanol as a solvent without the use of catalyst. In parallel, these reactions wereperformed under identical conditions of temperature using P2O5/SiO2 as a catalyst in different amounts.Results: A series of N-substituted 1-alkyl and 1-aryl- 3-aminoisoquinolines were synthesized using microwaveirradiation with as high selectivity, short reaction times and without the use of catalyst. The useof P2O5/SiO2 as catalyst under microwave irradiation conditions was not effective for these reactions.Conclusion: The results show an efficient method for the synthesis of N-substituted 1-alkyl and 1-aryl-3-aminoisoquinolines by the reaction of 2-acylphenylacetonitriles with amines using microwave irradiation.Some important advantages for this method include a strong decrease in reaction time, a good selectivity,and the absence of catalyst, with simplicity in operation and a benefit to the environment.
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