CINDECA 05422
CENTRO DE INVESTIGACION Y DESARROLLO EN CIENCIAS APLICADAS "DR. JORGE J. RONCO"
Unidad Ejecutora - UE
artículos
Título:
A Solvent-free method for synthesis of dihydroangelicins using microwaves
Autor/es:
G. ROMANELLI; J. AUTINO; D. RUIZ
Revista:
Current Green Chemistry
Editorial:
Bentham
Referencias:
Año: 2016 vol. 3 p. 242 - 247
ISSN:
2213-3461
Resumen:
dihydrofurocoumarins are a wide range of compounds, among them dihydroangelicins and dihydropsoralens, compounds present in various plant species with a varied biological activity. Several strategies have been developed for synthesize these compounds, and various catalysts were used for that purporse. In this work we report the synthesis of 8,9-dihydrofuran [2,3-h] coumarins using a strategy of alyloxycoumarins cycloaddition in sustainable conditions: absence of solvents, application of microwave radiation, and insoluble acid catalysis by means of heteropolyacids with Preyssler structure H14(NaP5MoW29O110)]. With these conditions we replace the use of solvents and mineral acids with great impact to the environment with a solid easily recoverable heteropolyacid.
