Influence of particle size on the adsorption and release of cephalexin encapsulated in mesoporous silica SBA-15

MARÍA S. LEGNOVERDE,; ELENA I. BASALDELLA

MATERIALS LETTERS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2016 vol. 181 p. 331 - 334

0167-577X

Ordered mesoporous silicas withdifferent particle sizes were synthesized and used as drug carrier in controlleddelivery systems. Morphological properties of mesoporous supports were modifiedby changing the stirring rate. Changes in the shape of SBA-15 from fiber-like particlesto smaller irregular agglomerates were obtained by reducing the stirring rate. Theadsorption and release of cephalexin from those different supports wereinvestigated. Adsorption capacity was found to increase with decreasing particlesizes, and the in vitro release experiments indicated a clear increase in theamount released from the smaller particles. In vivo studies revealed thatsilica matrixes effectively control the drug release and were capable ofmaintaining a sustained therapeutic blood level of cephalexin.