CENTRO DE INVESTIGACION Y DESARROLLO EN CIENCIAS APLICADAS "DR. JORGE J. RONCO"
Unidad Ejecutora - UE
Enzymatic kinetic resolution of racemic ibuprofen: past, present and future
CARLA JOSÉ; MARIA VICTORIA TOLEDO; LAURA E. BRIAND
CRITICAL REVIEWS IN BIOTECHNOLOGY
TAYLOR & FRANCIS INC
Lugar: Londres; Año: 2015 p. 1 - 1
This review is a journey concerning the investigations of the kinetic resolution of racemic ibuprofen for the last 20 years. The relevancy of the pharmacological uses of the S(+) enantiomer along with its higher cost compared with racemic profen are the driven forces of a variety of scientific research addressing the enzymatic resolution of ibuprofen through enantiomeric esterification using lipases as biocatalysts. Lipases of fungal sources such as Candida rugosa, Rhizomucor miehei and the lipase B of Candida antarctica have been extensively studied both in homogeneous and heterogeneous (immobilized on solid supports) processes. In this context, the various alcohols and organic co-solvents frequently used in the esterification of racemic ibuprofen are summarized and discussed in this review. Moreover, recent investigations using membranes as reactors coupled with the separation of the desired product and microfluidic devices are presented. Finally some guidelines about future perspectives of the technology of the kinetic resolution of profens and research niches are given.