Modified Silica Matrices for Controlled Release of Cephalexin

MARÍA S. LEGNOVERDE; IGNACIO JIMÉNEZ-MORALES; ENRIQUE RODRÍGUEZ-CASTELLÓN; ALBERTO JIMÉNEZ-MORALES; ELENA I. BASALDELLA

MEDICINAL CHEMISTRY

BENTHAM SCIENCE PUBL LTD

Año: 2013 vol. 9 p. 672 - 680

1573-4064

SBA-15 type ordered silicas possessing aminogroups attached onto their surfaces were prepared by using different functionalization methodologies. These matrices were used to study the kinetic of cephalexin adsorption from aqueous solution and further release into physiological solution. The materials were characterized by nitrogen adsorption/desorption, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), X-Ray photoelectron spectrometry (XPS) and thermo analytical methods (TG/DSC). UV?visible spectroscopy at 262 nm was used for quantitative determination of cephalexin present in liquid media. Results reveal that drug adsorption capacities and the corresponding release profiles are dependent on the number of loaded aminogroups, which in turn is determined by the functionalization procedure used. It was concluded amino post-functionalization could enhance long-term cephalexin delivery in comparison with co-functionalization procedure.