CENTRO DE INVESTIGACION Y DESARROLLO EN CIENCIAS APLICADAS "DR. JORGE J. RONCO"
Unidad Ejecutora - UE
STUDIES OF CIPROFLOXACIN ENCAPSULATION ON ALGINATE/PECTIN MATRIXES AND ITS RELATIONSHIP WITH BIODISPONIBILITY
G.A. ISLAN; I.O. PÉREZ DE BERTI; .G. MARCHETTI; G.R. CASTRO
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
HUMANA PRESS INC
Lugar: Oregon; Año: 2012 vol. 167 p. 1408 - 1408
Abstract Screening of ciprofloxacin (Cip) with selected biopolymers brings about 90%antibiotic interactions with a coacervate composed of alginate/high metoxylated pectin in 2:1ratio. Fourier transform infrared spectroscopy analysis provides information about the natureof this interaction, revealing ionic and hydrophobic patterns among the molecules. Alginate/high methoxylated pectin gel microspheres developed by ionic gelation encapsulates 46.8±5.0% Cip. The gel matrix can release Cip in a sustained manner, releasing 42.7±0.2% in 2 hunder simulated stomach pH conditions, and 83.3±1.1% Cip release in 80 mM phosphate atpH07.40 (intestinal). The increase of sodium chloride from 50 to 200 mM implies a Ciprelease from 69.0±1.5% to 95.1±3.6% respectively in 2 h. Scanning electron microscopyrevealed the cohesive effect of HM pectin over alginate molecules on the microspheresurface. Those results guarantee all Cip contained in the alginate/HM pectin microspherescould be released in an established kinetic profile along the gastrointestinal tract, avoidingthe Cip undesirable side effects during absorption.