CONICET | Buscador de Institutos y Recursos Humanos

H6P2W18O62.24H2O bulk and silica supported catalysis were founds to be an efficient and recyclable catalysts for the synthesis of a series of â-aminocrotonates using toluene as solvent or under no reaction solvent conditions. Several substituted â-aminocrotonates can be prepared in very good yields and purity by direct reaction of amines and 1,3-dicarbonyl compounds in the presence of a catalytic amount of bulk and silica gel-supported H6P2W18O62.24H2O. The title compounds were prepared in very good yields using both methodologies, and no secondary products were detected. The using no reaction solvent procedure results in a clean and useful alternative, which has the advantages of a greener methodology with operative simplicity, use of a reusable and noncorrosive solid catalyst, soft reaction conditions, low reaction times, and good yields.