CENTRO DE INVESTIGACION Y DESARROLLO EN CIENCIAS APLICADAS "DR. JORGE J. RONCO"
Unidad Ejecutora - UE
Towards a rational design of enantioselective heterogeneous catalysts: Modeling of chiral organotin precursors
JOSÉ F. RUGGERA; ANDREA B. MERLO; VIRGINIA VETERE; MÓNICA L. CASELLA
JOURNAL OF MOLECULAR STRUCTURE THEOCHEM
ELSEVIER SCIENCE BV
Año: 2010 vol. 953 p. 91 - 91
In this work, the modeling of organotin compounds of general formula Men-Sn-R3 (Men = menthyl, R = alkyl or alkoxyalkyl) is carried out. These compounds can be employed as precursors for obtaining enantioselective heterogeneous catalysts, prepared by means of Surface Organometallic Chemistry on Metals techniques. Both Molecular Mechanics and Molecular Dynamics, as well as Density Functional Theory (DFT), were used to give an insight into the relative stability of the SnC bonds of several different organotin compounds. The calculations carried out on the molecules Men-Sn-(iso-Bu)3 and Men-Sn-((1-OCH3)-Et)3 showed that if these molecules are used as precursor compounds to prepare heterogeneous organobimetallic catalysts, the probability of losing the menthyl group in a dissociation process is lower, leading to a better performance of the resulting catalysts, in terms of enantiomeric excess.