CINDECA   05422
CENTRO DE INVESTIGACION Y DESARROLLO EN CIENCIAS APLICADAS "DR. JORGE J. RONCO"
Unidad Ejecutora - UE
artículos
Título:
An Efficient One-Step Hantzsch Multicomponent Synthesis of 1,4-Dihydropyridines Via a Wells-Dawson Heteropolyacid Catalyst Under Solvent-Free Conditions
Autor/es:
ANGEL G. SATHICQ; GUSTAVO ROMANELLI; AGUSTÍN PONZINIBBIO; GRACIELA T. BARONETTI; HORACIO J. THOMAS
Revista:
LETTERS IN ORGANIC CHEMISTRY
Editorial:
BENTHAM SCIENCE PUBL LTD
Referencias:
Año: 2010 vol. 7 p. 511 - 511
ISSN:
1570-1786
Resumen:
Abstract: In this work, we report the use of bulk Wells-Dawson acid (H6P2W18O62.24H2O) as a reusable, heterogeneous catalyst to obtain substituted 1,4-dihydropyridines for the Hantzsch multicomponent reaction, using various aldehydes, alkyl acetylacetates and ammonium acetate or aniline as source of ammonia. The reaction experiments were performed in the absence of solvent, at 80ºC. Under these conditions fourteen examples were obtained with very good yields (90-98%) and high selectivity. The catalyst was easily recycled and reused without appreciable loss of their catalytic activity. The synthetic method presented is a simple, clean and environmentally friendly alternative for obtaining substituted dihydropyridines
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