CINDECA   05422
CENTRO DE INVESTIGACION Y DESARROLLO EN CIENCIAS APLICADAS "DR. JORGE J. RONCO"
Unidad Ejecutora - UE
artículos
Título:
deactivation of Novozym 435 during the esterification of Ibuprofen whit ethanol: evidences of the detrimental effect of the alcohol
Autor/es:
CARLA JOSÉ; LAURA E. BRIAND
Revista:
Reaction Kinetics, Mechanism and Catalysis
Editorial:
SPRINGER
Referencias:
Año: 2010 vol. 99 p. 17 - 17
ISSN:
1878-5190
Resumen:
ABSTRACT The stability of Novozym 435 in the esterification of ibuprofen using ethanol as reactant and  solvent was  investigated. Additionally,  the  surface  interaction of  the isomers  of  ibuprofen  and  ethanol  with  the  biocatalyst  was  screened  through conventional  adsorption  isotherms  and  temperature  programmed  surface  reaction (TPSR). These investigations evidenced strong alcohol adsorption and dissolution of  the biocatalyst which explains  its deactivation upon reuses  in  the esterification reaction.
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