CINDECA 05422
CENTRO DE INVESTIGACION Y DESARROLLO EN CIENCIAS APLICADAS "DR. JORGE J. RONCO"
Unidad Ejecutora - UE
artículos
Título:
deactivation of Novozym 435 during the esterification of Ibuprofen whit ethanol: evidences of the detrimental effect of the alcohol
Autor/es:
CARLA JOSÉ; LAURA E. BRIAND
Revista:
Reaction Kinetics, Mechanism and Catalysis
Editorial:
SPRINGER
Referencias:
Año: 2010 vol. 99 p. 17 - 22
ISSN:
1878-5190
Resumen:
ABSTRACT
The stability of Novozym 435 in the esterification of ibuprofen using ethanol as
reactant and solvent was investigated. Additionally, the surface interaction of the
isomers of ibuprofen and ethanol with the biocatalyst was screened through
conventional adsorption isotherms and temperature programmed surface reaction
(TPSR). These investigations evidenced strong alcohol adsorption and dissolution
of the biocatalyst which explains its deactivation upon reuses in the esterification
reaction.
